After the sad demise of Hakeem Abdul Majeed, his son, Hakeem Abdul Hameed took over the administration of Hamdard at the age of 14 in 1922. He brought the dynamism of a new age to the philosophy and operations of Hamdard. He tried his best to bring the Unani System of Medicine on Modern Scientific lines. He expended the Business and started the activities in a spacious Building situated by the side of the main road which is now known as Hamdard Road, at Lal Kuan. This building had a glittering showroom in the front (which continues till this date). There was another beautiful building situated at the back of the showroom across bylane.

It had a wide courtyard with a large fountain in the middle, with rooms all around serving as clinic and offices and also an extensive factory at the very back. This factory had latest machines. The manual work was replaced by mechanical processes. There were machines for making tablets at high speed and machines for bottling and packing of liquids/syrups. He set up modern laboratories and subjected the various drugs to laboratory tests and made Hamdard a premier pharmaceutical house with a totally indigenous base. In this great endeavor, his younger brother, Hakeem Hafiz Muhammad Said gave full cooperation for attaining the objectives of the enterprise.

The exemplary life of Hakeem Abdul Hameed spanned almost the entire 20th Century. He gave a new life to the Unani system of Medicine at a time when it had stagnated beyond belief. For this contribution, he won international recognition and was honored through various awards like Padma Shri and Padma Bhushan by the Government of India, Avicenna Award from the USSR, Membership of the prestigious Iranian National Academy of Science, D.Litt. from Hamdard University Karachi and IRCICA Award given posthumously by the President of Turkey in 2000.